Possible minor shipping delays thru December.
Alpha GPC - L-Alpha glycerylphosphorylcholine Powder (NEW)
Email a friend
Alpha GPC - L-Alpha glycerylphosphorylcholine Powder (NEW)
Write a Review
50% Pure (to prevent clumping)
Put me on the Waiting List
Add to Cart
Disclaimer - Must Read
Alpha-GPC (alpha-glycerophosphocholine or choline alphoscerate) is a choline-containing phospholipid. When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. Glycerol-1-phosphate is used to support cellular membranes.
Alpha-GPC appears to easily cross the blood-brain barrier and is rapidly absorbed. It is currently the best cholinergic for increasing plasma and brain choline levels.
Oral supplementation of alpha-GPC is primarily of interest for nootropic or cognitive-enhancement purposes. There are a number of rodent studies that support this effect, but it has yet to be shown in otherwise healthy humans. In older adults with mild to moderate dementia — which involves disrupted cholinergic neurotransmission — alpha-GPC improves cognitive symptoms (e.g., memory and attention impairment). Alpha-GPC may also improve the effectiveness of acetylcholinesterase inhibitors (i.e., drugs that increase acetylcholine availability by slowing down its breakdown), which are used for treating Alzheimer’s disease.
Athletes are another population that may benefit from alpha-GPC supplementation. Preliminary evidence suggests that alpha-GPC increases vertical jump power. Additionally, a pilot study reported that alpha-GPC increased peak bench press force, but not peak power or rate of force development. Whether alpha-GPC increases isometric strength is currently unclear.
Mechanistic evidence suggests that alpha-GPC exerts its effects by increasing the synthesis and release of acetylcholine in the brain, where it is involved in memory, motivation, arousal, and attention.
Acetylcholine is also responsible for the action potential that stimulates muscles to contract. Therefore, it’s theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and, consequently, increased force production.
1.^Enea Traini, Vincenzo Bramanti, Francesco AmentaCholine alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agentCurr Alzheimer Res.(2013 Dec)
2.^G Gatti, N Barzaghi, G Acuto, G Abbiati, T Fossati, E PeruccaA comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteersInt J Clin Pharmacol Ther Toxicol.(1992 Sep)
3.^De Jesus Moreno Moreno MCognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trialClin Ther.(2003 Jan)
4.^Parker A, Byars A, Purpura M, Jager RThe effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agilityJ Int Soc Sports Nutr.(2015 Sep)
5.^Lena Marcus, Jason Soileau, Lawrence W Judge, David BellarEvaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performanceJ Int Soc Sports Nutr.(2017 Oct 5)
6.^Ziegenfuss T, Landis J, Hofheins JJ Int Soc Sports Nutr.()
7.^David Bellar, Nina R LeBlanc, Brian CampbellThe effect of 6 days of alpha glycerylphosphorylcholine on isometric strengthJ Int Soc Sports Nutr.(2015 Nov 17)
8.^Amy M Brownawell, Edward L Carmines, Federica MontesanoSafety assessment of AGPC as a food ingredientFood Chem Toxicol.(2011 Jun)
9.^Yongzhong Zhao, Zeneng WangImpact of trimethylamine N-oxide (TMAO) metaorganismal pathway on cardiovascular diseaseJ Lab Precis Med.(2020 Apr)
10.^Gyeongsil Lee, Seulggie Choi, Jooyoung Chang, Daein Choi, Joung Sik Son, Kyuwoong Kim, Sung Min Kim, Seogsong Jeong, Sang Min ParkAssociation of L-a Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 YearsJAMA Netw Open.(2021 Nov 1)
11.^Zeneng Wang, Jennie Hazen, Xun Jia, Elin Org, Yongzhong Zhao, Lucas J Osborn, Nisreen Nimer, Jennifer Buffa, Miranda K Culley, Daniel Krajcik, Bert-Jan H van den Born, Koos Zwinderman, Bruce S Levison, Max Nieuwdorp, Aldons J Lusis, Joseph A DiDonato, Stanley L HazenThe Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes AtherosclerosisInt J Mol Sci.(2021 Dec 15)
12.^Seyed Khosrow Tayebati, Daniele Tomassoni, Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Francesco AmentaEffect of choline-containing phospholipids on brain cholinergic transporters in the ratJ Neurol Sci.(2011 Mar 15)
13.^Francesco Amenta, Seyed Khosrow Tayebati, Daniela Vitali, Maria Antonietta Di TullioAssociation with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmissionMech Ageing Dev.(2006 Feb)
14.^M Trabucchi, S Govoni, F BattainiChanges in the interaction between CNS cholinergic and dopaminergic neurons induced by L-alpha-glycerylphosphorylcholine, a cholinomimetic drugFarmaco Sci.(1986 Apr)
15.^C M Lopez, S Govoni, F Battaini, S Bergamaschi, A Longoni, C Giaroni, M TrabucchiEffect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholinePharmacol Biochem Behav.(1991 Aug)
Select a row below to filter reviews.
Average Customer Ratings
most helpful to least helpful
high to low rating
low to high rating
newest to oldest
oldest to newest
If you're making your own nootropic stacks, this is a 100% must have. If I do not take alpha GPC when I take nootropics or stronger stims, I get headaches due to choline depletion. This keeps the tank full and focus/mental energy lasting longer.
Did you find this helpful?
from Chapel Hill on 11/23/2022
Your use of this website constitutes your agreement to be bound by these terms and conditions.
Legal disclaimer from BulkStimulants.com, please read:
The chemicals/materials for sale here are intended for laboratory and research use only, unless otherwise explicitly stated. They are not intended for human ingestion or for use in products that may be ingested. You must be at least 18 (eighteen) years of age to purchase goods on this website. The listing of a material on this website does not constitute a license to, or a recommendation for its use in infringement of any patent whatsoever. It is understood that all of the products purchased here will be handled only by qualified and trained individuals. In purchasing these products, the customer acknowledges that there are hazards associated with their handling and use. Customer represents and warrants to us that from customer’s own independent review and study they are fully aware and knowledgeable about (I) the health and safety hazards associated with the handling of the products purchased; (II) industrial hygiene controls necessary to protect its workers from such health and safety hazards; (III) the need to adequately warn of health and safety hazards associated with products; and (IV) government regulations regarding the use of and exposure to such products. We reserve the right to limit sales of products or not to sell products to unqualified customers. In no event shall BulkStimulants.com, or any of its affiliates be liable for special, incidental or consequential damages, whether purchaser’s claim in contract, negligence, strict liability or otherwise. In consideration of the sale of the product to the purchaser, which sales we would not otherwise make, purchaser agrees to indemnify and hold BulkStimulants.com harmless from all claims, expenses, losses and liability of any nature whatsoever arising out of purchaser’s handling and/or use of any product sold here, whether used alone or in combination with any other substance no matter what it’s origination. Use of Products: Suppliers products are intended only for research purposes unless otherwise explicitly stated. The purposes not intended for products sold here include but not limited to, in vitro diagnostic purposes, in foods, drugs, medical devices, or cosmetics for humans or animals or for commercial purposes. Buyer acknowledges that the products have not been tested by supplier for safety and efficacy in food, drug, and medical device, cosmetic, commercial or any other use. Buyer expressly represents and warrants to supplier that Buyer will properly test and use any products purchased from supplier and/or materials produced with products purchased from supplier in accordance with the practices of any reasonable person who is an expert in any appropriate scientific field of study and in strict compliance with all applicable state and federal laws and regulations, now and hereinafter enacted. Buyer further warrants to supplier that any material produced with products from supplier shall not be adulterated or misbranded within the meaning of the Federal Food, Drug and Cosmetic Act and shall not be materials which may not, under Sections 404, 505, or 512 of the Act, be introduced into interstate commerce. Buyer realizes that, since supplier products are, unless otherwise stated, intended primarily for research purposes nothing else, they may not be on the Toxic Substances Control Act (TSCA) inventory. Buyer assumes responsibility to assure that the products purchased from supplier are approved for use under TSCA, if applicable. Buyer has the responsibility to verify the hazards and to conduct any further research necessary to learn the hazards involved in using products purchased from supplier. Buyer also has the duty to warn Buyer’s customers and any auxiliary personnel (such as freight handlers, etc.) of any risks involved in using or handling the products. Buyer agrees to comply with instructions, if any, furnished by supplier relating to the use of the products and not misuse of the products in any manner. Buyer agrees that any and all products here are not intended for resale purposes. If the products purchased from supplier are repackaged, relabeled or used as starting material or components of other products, Buyer will verify supplier assay of the products. ALL products and services offered are for laboratory and research activities exclusively. By placing orders with this company it we understood by the buyer that under no circumstances should use any of these chemicals/materials in an inappropriate manner. No products here are to be used for recreational purposes nor human consumption. All customers are assumed and expected to be qualified researchers.
Peak ATP (Adenosine Triphosphate) Powder - 100% Pure
Dynamine (Methylliberine) Powder - NEW Tasteless Formula
TeaCrine (Theacrine) Powder
Recently Viewed Items
Turn History Off